Enzymatic Deamination of the Epigenetic BaseN-6-Methyladenine

The Enzymatic Deamination of Amphetamine

A previous st,udy on the metabolism of amphetamine (1-phenyl-2-aminopropane), widely used as a stimulant of the central nervous system, showed that its major route of biotransformation in the rat and dog involved hydroxylation of the aromatic ring. In the rabbit, however, the compound was not hydroxylated, but was found to be transformed in another manner (2). The present report describes an en...

The enzymatic deamination of amphetamine (benzedrine).

N6-methyladenine: a potential epigenetic mark in eukaryotes

Methylation modifications in DNA in the forms of 5-methylcytosine (5mC) and N 6-methyladenine (6mA) are one of the most important epigenetic marks that have been proposed to regulate gene expression and control numerous cellular and biological processes. The prevailing view is that, while 5mC serves as the predominant type, if not the only type, of methylated base in mammals to regulate gene ex...

Enzymatic deamination of 8-azaguanine in normal and neoplastic tissues.

Chemical carcinogens in non-enzymatic cytosine deamination: 3-isocyanatoacrylonitrile

Uracil has long been known as the main product of nitrosative cytosine deamination in aqueous solution. Recent mechanistic studies of cytosinediazonium ion suggest that the cation formed by its dediazoniation can ring-open to N-protonated (Z,s-cis)-3-isocyanatoacrylonitrile 7. Stereochemical preferences are discussed of the 3-isocyanatoacrylonitriles (Z,s-cis)-10, (E,s-cis)-11, (Z,s-trans)-12, ...